Publications
1963-1975
1. Richardson, C. C., Schildkraut, C. L., Aposhian, H. V., Kornberg, A., Bodmer, W., and Lederberg, J. (1963) Studies on the replication of DNA by Escherichia coli polymerase, in Informational Macromolecules (Ed. H. Vogel), Academic Press, Inc., New York, pp. 13-26.
2. Richardson, C. C., Schildkraut, C. L., and Kornberg, A. (1963) Studies on the replication of DNA by DNA polymerases. Cold Spring Harbor Symp. Quant. Biol. 28, 9-19.
3. Richardson, C. C., Schildkraut, C. L., Aposhian, H. V., and Kornberg, A. (1964) Enzymatic synthesis of deoxyribonucleic acid, XIV. Further purification and properties of deoxyribonucleic acid polymerase of Escherichia coli. J. Biol. Chem. 239, 222-232.
4. Lehman, I. R., and Richardson, C. C. (1964) The deoxyribonucleases of Escherichia coli. IV. An exonuclease activity present in purified preparations of deoxyribonucleic acid polymerase. J. Biol. Chem. 239, 233-241.
5. Richardson, C. C., and Kornberg, A. (1964) A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli, I. Purification of the enzyme and characterization of the phosphatase activity. J. Biol. Chem. 239, 242-250.
6. Richardson, C. C., Lehman, I. R., and Kornberg, A. (1964) A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli, II. Characterization of the exonuclease activity. J. Biol. Chem. 239, 251-258.
7. Schildkraut, C.L., Richardson, C. C., and Kornberg, A. (1964) Enzymatic synthesis of deoxyribonucleic acid, XVII. Some unusual physical properties of the product primed by native DNA templates. J. Mol. Biol. 9, 24-45.
8. Richardson, C. C., Inman, R. B., and Kornberg, A. (1964) Enzymatic synthesis of deoxyribonucleic acid, XVIII. The repair of partially single-stranded DNA templates by DNA polymerase. J. Mol. Biol. 9, 46-69.
9. Lehman, I. R., Linn, S., and Richardson, C. C. (1965) Nucleases as reagents in the study of nucleic acid structure. Federation Proc. 24, 1466-1472.
10. Richardson, C. C., (1965) Phosphorylation of nucleic acid by an enzyme from T4 bacteriophage-infected Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 54, 158-165.
11. Richardson, C. C. (1966) The 5'-terminal nucleotides of T7 bacteriophage deoxyribonucleic acid. J. Mol. Biol. 15, 49-61.
12. Richardson, C. C. (1966) Influence of glucosylation of deoxyribonucleic acid on hydrolysis by deoxyribonucleases of Escherichia coli. J. Biol. Chem. 241, 2064-2092.
13. Richardson, C. C., and Weiss, B. (1966) The enzymatic phosphorylation of nucleic acids and its application to end-group analysis. J. Gen. Physiol. 49, 81-97.
14. Richardson, C. C. (1966) DNA polymerase from Escherichia coli. In Procedures in Nucleic Acid Research (Eds. G. L. Cantoni and D. R. Davies), Harper and Row, New York, pp. 263-276.
15. Richardson, C. C. (1966) Exonuclease III from Escherichia coli. In Procedures in Nucleic Acid Research (Eds. G. L. Cantoni and D. R. Davies), Harper and Row, New York, pp. 212-223.
16. Weiss, B., and Richardson, C. C. (1967) End-group labeling of nucleic acids by enzymatic phosphorylation. Cold Spring Harbor Symp. Quant. Biol. 31, 471-478.
17. Weiss, B., and Richardson, C. C. (1967) The 5'-terminal dinucleotides of the separated strands of T7 bacteriophage deoxyribonucleic acid. J. Mol. Biol. 23, 405-415.
18. MacHattie, L., Ritchie, D., Thomas, C. A., Jr., and Richardson, C. C. (1967) Terminal repetition in permuted T2 bacteriophage DNA molecules. J. Mol. Biol. 23, 355-363.
19. Weiss, B., and Richardson, C. C. (1967) Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage. Proc. Natl. Acad. Sci., U.S.A. 57, 1021-1028.
20. Fareed, G. C., and Richardson, C. C. Enzymatic breakage and joining of deoxyribonucleic acid, II. The structural gene for polynucleotide ligase in bacteriophage T4. (1967) Proc. Natl. Acad. Sci., U.S.A. 58, 665-672.
21. Weiss, B., and Richardson, C. C. (1967) Enzymatic breakage and joining of deoxyribonucleic acid, III. An enzyme-adenylate intermediate in the polynucleotide ligase reaction. J. Biol. Chem. 242, 4270-4272.
22. Richardson, C. C., Masamune, Y., Live, T. R., Jacquemin-Sablon, A., Weiss, B., and Fareed, G. C. (1968) Studies on the joining of DNA by polynucleotide ligase of phage T4. Cold Spring Harbor Symp. Quant. Biol. 33, 151-164.
23. Masamune, Y., and Richardson, C. C. (1968) Enzymatic breakage and joining of deoxyribonucleic acid, IV. DNA synthesis in E. coli infected with ligase-negative mutants of phage T4. Proc. Natl. Acad. Sci., U.S.A. 61, 1328-1335.
24. Weiss, B., Live, T. R., and Richardson, C. C. (1968) Enzymatic breakage and joining of deoxyribonucleic acid, V. End-group labeling and is id containing single-strand breaks. J. Biol. Chem. 243, 4530-4542.
25. Weiss, B., Jacquemin-Sablon, A., Live, T. R., Fareed, G. C., and Richardson, C. C. (1968) Enzymatic breakage and joining of deoxyribonucleic acid, VI. Further purification and properties of polynucleotide ligase from Escherichia coli infected with bacteriophage T4. J. Biol. Chem. 243, 4543-4555.
26. Weiss, B., Thompson, A., and Richardson, C. C. (1968) Enzymatic breakage and joining of deoxyribonucleic acid, VII. Properties of the enzyme-adenylate intermediate in the polynucleotide ligase reaction. J. Biol. Chem. 243, 4556-4563.
27. Richardson, C. C. (1968) Enzymes in DNA metabolism. Ann. Rev. Biochem. 38, 795-840.
28. Jacquemin-Sablon, A., and Richardson, C. C. (1970) Analysis of the interruptions in bacteriophage T5 DNA. J. Mol. Biol. 47, 477-493.
29. Center, M. S., Studier, F. W., and Richardson, C. C. (1970) The structural gene for a T7 endonuclease essential for phage DNA synthesis. Proc. Natl. Acad. Sci., U.S.A. 65, 242-248.
30. Moses, R. E., and Richardson, C. C. (1970) Replication and repair of DNA in cells of Escherichia coli treated with toluene. Proc. Natl. Acad. Sci., U.S.A. 67, 674-681.
31. Center, M. S., and Richardson, C. C. (1970) An endonuclease induced after infection of Escherichia coli with bacteriophage T7, I. Purification and properties of the enzyme. J. Biol. Chem. 245, 6285-6291.
32. Center, M. S., and Richardson, C. C. (1970) An endonuclease induced after infection of Escherichia coli with bacteriophage T7, II. Specificity of the enzyme toward single- and double-stranded deoxyribonucleic acid. J. Biol. Chem. 245, 6292-6299.
33. Moses, R. E., and Richardson, C. C. (1970) A new DNA polymerase activity of Escherichia coli, I. Purification and properties of the activity present in E. coli polA1. Biochem. Biophys. Res. Commun. 41, 1557-1564.
34. Moses, R. E., and Richardson, C. C. (1970) A new DNA polymerase activity of Escherichia coli, II. Properties of the enzyme purified from wild-type E. coli and DNAts mutants. Biochem. Biophys. Res. Commun. 41, 1565-1571.
35. Richardson, C. C. (1971) Polynucleotide kinase from Escherichia coli infected with bacteriophage T4. In Procedures in Nucleic Acid Research, Vol. II (Eds. G. L. Cantoni and D. R. Davies), Harper and Row, New York, pp. 815-828.
36. Fareed, G. C., Wilt, E. M., and Richardson, C. C. (1971) Enzymatic breakage and joining of deoxyribonucleic acid, VIII. Hybrids of ribo- and deoxyribonucleotide homopolymers as substrates for polynucleotide ligase of bacteriophage T4. J. Biol. Chem. 246, 925-932.
37. Masamune, Y., Fleischman, R. A., and Richardson, C. C. (1971) Enzymatic removal and replacement of nucleotides at single-strand breaks in deoxyribonucleic acid. J. Biol. Chem. 246, 2680-2691.
38. Masamune, Y., and Richardson, C. C. (1971) Strand displacement during deoxyribonucleic acid synthesis at single-strand breaks. J. Biol. Chem. 246, 2692-2701.
39. Frenkel, G. D., and Richardson, C. C. (1971) The deoxyribonuclease induced after infection of Escherichia coli by bacteriophage T5, I. Characterization of the enzyme as a 5'-exonuclease. J. Biol. Chem. 246, 4839-4847.
40. Frenkel, G. D., and Richardson, C. C. (1971) The deoxyribonuclease induced after infection of Escherichia coli by bacteriophage T5, II. Role of the enzyme in replication of the phage deoxyribonucleic acid. J. Biol. Chem. 246, 4848-4852.
41. Moses, R. E., Campbell, J. L., Fleischman, R. A., and Richardson, C. C. (1971) Enzymatic mechanisms in DNA replication. In Nucleic Acid-Protein Interactions and Nucleic Acid synthesis in Viral Infection, Miami Winter Symposia, Vol. 2, (Eds. D. W. Ribbons, J. F. Woessner, and J. Schultz), North-Holland Publishing Co., Amsterdam, pp. 48-69.
42. Harvey, C. L., Gabriel, T. F., Wilt, E. M., and Richardson, C. C. (1971) Enzymatic breakage and joining of deoxyribonucleic acid, IX. Synthesis and properties of the deoxyribonucleic acid adenylate in the phage T4 ligase reaction. J. Biol. Chem. 246, 4523-4530.
43. Fleischman, R. A., and Richardson, C. C. (1971) Analysis of host range restriction in Escherichia coli treated with toluene. Proc. Natl. Acad. Sci., U.S.A. 68, 2527-2531.
44. Grippo, P., and Richardson, C. C. (1971) DNA polymerase of bacteriophage T7. J. Biol. Chem. 246, 6867-6873.
45. Masamune, Y., Frenkel, G. D., and Richardson, C. C. (1971) A mutant of bacteriophage T7 deficient in polynucleotide ligase. J. Biol. Chem. 246, 6874-6879.
46. Campbell, J. L., Soll, L., and Richardson, C. C. (1972) Isolation and partial characterization of a mutant of Escherichia coli deficient in DNA polymerase II. Proc. Natl. Acad. Sci., U.S.A. 69, 2090-2094.
47. Scheffler, I. E., and Richardson, C. C. (1972) Chemical and enzymatic studies of deoxyribonucleic acid covalently linked to Ficoll. J. Biol. Chem. 247, 5736-5745.
48. Moses, R. E., Campbell, J. L., Fleischman, R. A., Frenkel, G. D., Mulcahy, H. L., Shizuya, H., and Richardson, C. C. (1972) Enzymatic mechanisms of DNA replication in Escherichia coli. Federation Proc. 31, 1415-1421.
49. Richardson, C. C., Campbell, J. L., Chase, J. W., Hinkle, D. C., Livingston, D. M., Mulcahy, H. L., and Shizuya, H. (1973) DNA polymerases of Escherichia coli. In DNA Synthesis in vitro (Eds. R. D. Wells and R. B. Inman), University Park Press, Baltimore, Maryland, pp. 65-69.
50. Hinkle, D. C., and Richardson, C. C. (1974) Bacteriophage T7 deoxyribonucleic acid replication in vitro: Requirements for deoxyribonucleic acid synthesis and characterization of the product. J. Biol. Chem. 249, 2974-2984.
51. Chase, J. W., and Richardson, C. C. (1974) Exonuclease VII of Escherichia coli: Purification and properties. J. Biol. Chem. 249, 4545-4552.
52. Chase, J. W., and Richardson, C. C. (1974) Exonuclease VII of Escherichia coli: Mechanism of action. J. Biol. Chem. 249, 4553-4561.
53. Shizuya, H., and Richardson, C. C. (1974) Synthesis of bacteriophage lambda DNA in vitro: Requirements for O and P gene products. Proc. Natl. Acad. Sci., U.S.A. 71, 2614-2617.
54. Shizuya, H., Livingston, D. M., and Richardson, C. C. (1974) Isolation of a specialized transducing phage lambda carrying the polC locus of Escherichia coli. Proc. Natl. Acad. Sci., U.S.A. 71, 2614-2617.
55. Campbell, J. L., Shizuya, H., and Richardson, C. C. (1974) Mapping of a mutation, polB100, affecting deoxyribonucleic acid polymerase II in Escherichia coli K-12. J. Bacteriol. 119, 494-499.
56. Chase, J. W., and Richardson, C. C. (1975) Exonuclease VII of Escherichia coli, in Molecular Mechanisms for Repair of DNA, Part A (Eds. P. C. Hanawalt and R. B. Setlow), Plenum Publishing Corp., New York, pp. 225-234.
57. Livingston, D. M., Hinkle, D. C., and Richardson, C. C. (1975) Deoxyribonucleic acid polymerase III of Escherichia coli: Purification and properties. J. Biol. Chem. 250, 461-469.
58. Livingston, D. M., and Richardson, C. C. (1975) Deoxyribonucleic acid polymerase III of Escherichia coli: Characterization of associated exonuclease activities. J. Biol. Chem. 250, 470-478.
59. Modrich, P., and Richardson, C. C. (1975) Bacteriophage T7 deoxyribonucleic acid replication in vitro: A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. J. Biol. Chem. 250, 5508-5514.
60. Modrich, P., and Richardson, C. C. (1975) Bacteriophage T7 deoxyribonucleic acid replication in vitro: An enzyme composed of phage- and host-specified subunits. J. Biol. Chem. 250, 5515-5522.
61. Hinkle, D. C., and Richardson, C. C. (1975) Bacteriophage T7 deoxyribonucleic acid replication in vitro: Purification and properties of the gene 4 protein of bacteriophage T7. J. Biol. Chem. 250, 5523-5529.
62. Masker, W. E., and Richardson, C. C. (1976) Bacteriophage T7 deoxyribonucleic acid replication in vitro. V. Synthesis of intact chromosomes of bacteriophage T7. J. Mol. Biol. 100, 543-556.
63. Masker, W. E., and Richardson, C. C. (1976) Bacteriophage T7 deoxyribonucleic acid replication in vitro. VI. Synthesis of biologically active T7 DNA. J. Mol. Biol. 100, 557-567.
1976-1980
64. Fleischman, R. A., Campbell, J. L., and Richardson, C. C. (1976) Modification and restriction of T-even bacteriophages. In vitro degradation of deoxyribonucleic acid containing 5-hydroxymethylcytosine. J. Biol. Chem. 251, 1561-1570.
65. Mark, D. F., and Richardson, C. C. (1976) Escherichia coli thioredoxin: A subunit of bacteriophage T7 DNA polymerase. Proc. Natl. Acad. Sci., U.S.A. 73, 780-784.
66. Chase, J. W., and Richardson, C. C. (1977) Escherichia coli mutants deficient in exonuclease VII. J. Bacteriol. 129, 934-947.
67. Kolodner, R., and Richardson, C. C. (1977) Replication of duplex DNA by bacteriophage T7 DNA polymerase and gene 4 protein is accompanied by hydrolysis of nucleoside 5'-triphosphates. Proc. Natl. Acad. Sci., U.S.A. 74, 1525-1529.
68. Mark, D. F., Chase, J. W., and Richardson, C. C. (1977) Genetic mapping of trxA, a gene affecting thioredoxin in Escherichia coli K12. Molec. Gen. Genet. 155, 145-152.
69. Masamune, Y., and Richardson, C. C. (1977) Priming of deoxyribonucleic acid synthesis on phage fd and øX174 templates by oligoribonucleotides contaminating nucleoside 5'-triphosphates. J. Biol. Chem. 252, 145-152.
70. Kolodner, R., Masamune, Y., LeClerc, J. E., and Richardson, C. C. (1978) Gene 4 protein of bacteriophage T7. Purification, physical properties, and stimulation of T7 DNA polymerase during the elongation of polynucleotide chains. J. Biol. Chem. 253, 566-573.
71. Kolodner, R., and Richardson, C. C. (1978) Gene 4 protein of bacteriophage T7. Characterization of the product synthesized by the T7 DNA polymerase and gene 4 protein in the absence of ribonucleoside 5'-triphosphates. J. Biol. Chem. 253, 574-584.
72. Campbell, J. L., Richardson, C. C., and Studier, F. W. (1978) Genetic recombination between bacteriophage T7 and cloned fragments of T7 DNA. Proc. Natl. Acad. Sci., U.S.A. 75, 2276-2280.
73. Richardson, C. C., Romano, L. J., Kolodner, R., LeClerc, J. E., Tamanoi, F., Engler, M. J., Dean, F. B., and Richardson, D. S. (1979) Replication of bacteriophage T7 DNA by purified proteins. Cold Spring Harbor Symp, Quant. Biol. 43, 427-440.
74. Campbell, J. L., Tamanoi, F., Richardson, C. C., and Studier. F. W. (1979) Cloning of the T7 genome in Escherichia coli: Use of recombination between cloned sequences and phage T7 to identify genes involved in recombination and a clone containing the origin of T7 DNA replication. Cold Spring Harbor Symp. Quant Biol. 43, 441-448.
75. Romano, L. J., and Richardson, C. C. (1979) Requirements for synthesis of ribonucleic acid primers during lagging-strand synthesis by the DNA polymerase and gene 4 protein of bacteriophage T7. J. Biol. Chem. 254, 10476-10482.
76. Romano, L. J., and Richardson, C. C. (1979) Characterization of the ribonucleic acid primers and the deoxyribonucleic acid product synthesized by the DNA polymerase and gene 4 protein of bacteriophage T7. J. Biol. Chem. 254, 10483-10489.
77. LeClerc, J. E., and Richardson, C. C. (1979) Gene 2 protein of bacteriophage T7: Purification and requirements for packaging of T7 DNA in vitro. Proc. Natl. Acad. Sci., U.S.A. 76, 4852-4856.
78. Hori, K., Mark, D. F., and Richardson, C. C. (1979) Deoxyribonucleic acid polymerase of bacteriophage T7. Purification and properties of the phage encoded subunit, the gene 5 protein. J. Biol. Chem. 254, 11591-11597.
79. Hori, K., Mark, D. F., and Richardson, C. C. (1979) Deoxyribonucleic acid polymerase of bacteriophage T7. Characterization of the exonuclease activities of the gene 5 protein and the reconstituted polymerase. J. Biol. Chem. 254, 11598-11604.
80. Tamanoi, F., Saito, H., and Richardson, C. C. (1980) Physical mapping of primary and secondary origins of bacteriophage T7 DNA replication. Proc. Natl. Acad. Sci., U.S.A. 77, 2656-2660.
81. Saito, H., Tabor, S., Tamanoi, F., and Richardson, C. C. (1980) Nucleotide sequence of the primary origin of bacteriophage T7 DNA replication: Relationship to adjacent genes and regulatory elements. Proc. Natl Acad. Sci., U.S.A. 77, 3917-3921.
82. Tamanoi, F., Engler, M. J., Lechner, R., Orr-Weaver, T., Romano, L. J., Saito, H., Tabor, S., and Richardson, C. C. (1980) Replication of bacteriophage T7 DNA. In Mechanistic Studies of DNA Replication and Genetic Recombination, ICN-UCLA Symposia on Molecular and Cellular Biology, Vol. XIX (Eds. B. Alberts and C. F. Fox), Academic Press, New York, pp. 411-428.
1981-1985
83. Saito, H., and Richardson, C. C. (1981) Genetic analysis of gene 1.2 of bacteriophage T7: Isolation of a mutant of Escherichia coli unable to support the growth of T7 gene 1.2 mutants. J. Virol. 37, 343-351.
84. Tabor, S., and Richardson, C. C. (1981) Template recognition sequence for RNA primer synthesis by the gene 4 protein of bacteriophage T7. Proc. Natl. Acad. Sci., U.S.A. 78, 205-209.
85. Romano, L. J., Tamanoi, F., and Richardson, C. C. (1981) Initiation of DNA replication at the primary origin of bacteriophage T7 by purified proteins: Requirement for T7 RNA polymerase. Proc. Natl. Acad. Sci., U.S.A. 78, 4107-4111.
86. Tabor, S., Engler, M. J., Fuller, C. W., Lechner, R. L., Matson, S. W., Romano, L. J., Saito, H., Tamanoi, F., and Richardson, C. C. (1981) Initiation of bacteriophage T7 DNA replication. In The Initiation of DNA Replication. ICN-UCLA Symposia on Molecular and Cellular Biology, Vol. XXII (Eds. D. Ray and C. F. Fox) Academic Press, New York, pp. 387-408.
87. Saito, H., and Richardson, C. C. (1981) Processing of mRNA by ribonuclease III regulates expression of gene 1.2 of bacteriophage T7. Cell 27, 533-542.
88. Richardson, C. C. (1981) Bacteriophage T4 polynucleotide kinase. In The Enzymes, Vol. XIV (Ed. P. D. Boyer) Academic Press, New York, pp. 299-314.
89. Engler, M. J., and Richardson, C. C. (1982) DNA ligases. In The Enzymes, Vol. XV (Ed. P. D. Boyer) Academic Press, New York, pp. 3-29.
90. Fuller, C. W., Beauchamp, B. B., Engler, M. J., Lechner, R. L., Matson, S. W., Tabor, S., White, J. H., and Richardson, C. C. (1983) Mechanisms for the initiation of bacteriophage T7 DNA replication. Cold Spring Harbor Symp. Quant. Biol. 47, 669-679.
91. Richardson, C. C. (1983) Bacteriophage T7: Minimal requirements for the replication of a duplex DNA molecule. Cell 33, 315-317.
92. Engler, M. J., Lechner, R. L., and Richardson, C. C. (1983) Two forms of the DNA polymerase of bacteriophage T7. J. Biol. Chem. 258, 11165-11173.
93. Lechner, R. L., Engler, M. J., and Richardson, C. C. (1983) Characterization of strand displacement synthesis catalyzed by bacteriophage T7 DNA polymerase. J. Biol. Chem. 258, 11174-11184.
94. Lechner, R. L., and Richardson, C. C. (1983) A preformed, topologically stable replication fork: Characterization of leading strand DNA synthesis catalyzed by T7 DNA polymerase and gene 4 protein. J. Biol. Chem. 258, 11185-11196.
95. Engler, M. J., and Richardson, C. C. (1983) Bacteriophage T7 DNA replication: Synthesis of lagging strands in a reconstituted system using purified proteins. J. Biol. Chem. 258, 11197-11205.
96. Richardson, C. C. (1983) Replication of bacteriophage T7 DNA. In Developments in Molecular Virology, Vol. 2, (Ed. Y. Becker), Martinus Nijhoff, pp. 93-100.
97. Richardson, C. C. (1983) The role of thioredoxin in bacteriophage T7 DNA replication. In Thioredoxins, Structure and Functions (Ed. P. Gadal), Editions du Centre National de la Recherche Scientifique, Paris, pp. 93-100.
98. Matson, S. W., Beauchamp, B. B., Engler, M. J., Fuller, C. W., Lechner, R. L., Tabor, S., White, J. H., and Richardson, C. C. (1983) Enzymatic mechanisms of T7 DNA replication. In Mechanisms of DNA Replication and Recombination, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 10 (Ed. N. R. Cozzarelli), Alan R. Liss, Inc., N.Y., pp. 135-151.
99. Matson, S. W., and Richardson, C. C. (1983) DNA dependent nucleoside 5'-triphosphatase activity of the gene 4 protein of bacteriophage T7. J. Biol. Chem. 258, 14009-14016.
100. Matson, S. W., Tabor, S., and Richardson, C. C. (1983) The gene 4 protein of bacteriophage T7: characterization of helicase activity. J. Biol. Chem. 258, 14017-14024.
101. Matson, S. W., and Richardson, C. C. (1985) Nucleotide dependent binding of the gene 4 protein of bacteriophage T7 to single-stranded DNA. J. Biol. Chem. 260, 2281-2287.
102. Fuller, C. W., and Richardson, C. C. (1985) Initiation of DNA replication at the primary origin of bacteriophage T7 by purified proteins: site and direction of initial DNA synthesis. J. Biol. Chem. 260, 3185-3196.
103. Fuller, C. W., and Richardson, C. C. (1985) Initiation of DNA replication at the primary origin of bacteriophage T7 by purified proteins: initiation of bidirectional synthesis. J. Biol. Chem. 260, 3197-3206.
104. Tabor, S., and Richardson, C. C. (1985) A bacteriophage T7 RNA polymerase/promoter system for the controlled, exclusive expression of specific genes. Proc. Natl. Acad. Sci., USA 82, 1074-1078.
1986-1990
105. Tabor, S., Huber, H. E., and Richardson, C. C. (1986) Escherichia coli thioredoxin: an accessory protein for bacteriophage T7 DNA polymerase. In Thioredoxin and Glutaredoxin Systems (Eds. A. Holmgren, C. Branden, H. Jornvall, and B. Sjoberg), Raven Press, N.Y., pp. 285-300.
106. Ikeda, R. A., and Richardson, C. C. (1986) Interactions of the RNA polymerase of bacteriophage T7 with its promoter during binding and initiation of transcription, Proc. Natl. Acad. Sci., USA 83, 3614-3618.
107. Huber, H. E., Russel, M., Model, P., and Richardson, C. C. (1986) Interaction of mutant thioredoxins of Escherichia coli with the gene 5 protein of phage T7. The redox potential of thioredoxin is not required for stimulation of DNA polymerase activity. J. Biol. Chem., 261, 15006-15012.
108. Nakai, H., and Richardson, C. C. (1986) Interactions of the DNA polymerase and gene 4 protein of bacteriophage T7: Protein-protein and protein-DNA interactions involved in RNA-primed DNA synthesis. J. Biol. Chem. 261, 15208-15216.
109. Nakai, H., and Richardson, C. C. (1986) Dissection of RNA-primed DNA synthesis catalyzed by gene 4 protein and DNA polymerase of bacteriophage T7: coupling of RNA primer and DNA synthesis. J. Biol. Chem. 261, 15217-15224.
110. Richardson, C. C., Beauchamp, B. B., Huber, H. E., Ikeda, R. A., Myers, J. A., Nakai, H., Rabkin, S. D., Tabor, S., and White, J. H. (1987) Bacteriophage T7 DNA replication. In Mechanisms of DNA Replication and Recombination, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 47, (Eds. T. Kelly and R. McMacken), Alan R. Liss, Inc., N.Y., pp. 151-171.
111. Ikeda, R. A., and Richardson, C. C. (1987) Enzymatic properties of a proteolytically nicked RNA polymerase of bacteriophage T7. J. Biol. Chem. 262, 3790-3799.
112. Ikeda, R. A., and Richardson, C. C. (1987) Interactions of a proteolytically nicked RNA polymerase of bacteriophage T7 with its promoter. J. Biol. Chem. 262, 3800-3808.
113. Myers, J. A., Beauchamp, B. B., White, J. H., and Richardson, C. C. (1987) Purification and characterization of the gene 1.2 protein of bacteriophage T7. J. Biol. Chem. 262, 5280-5287.
114. Myers, J. A., Beauchamp, B. B., and Richardson, C. C. (1987) Gene 1.2 protein of bacteriophage T7: effect on deoxyribonucleotide pools. J. Biol. Chem. 262, 5288-5292.
115. White, J. H., and Richardson, C. C. (1987) Gene 18 protein of bacteriophage T7: overproduction, purification, and characterization. J. Biol. Chem. 262, 8845-8850.
116. White, J. H., and Richardson, C. C. (1987) Processing of concatemers of bacteriophage T7 DNA in vitro. J. Biol. Chem. 262, 8851-8860.
117. Tabor, S., and Richardson, C. C. (1987) DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Proc. Natl. Acad. Sci., USA 84, 4767-4771.
118. Tabor, S., and Richardson, C. C. (1987) Selective oxidation of the exonuclease domain of bacteriophage T7 DNA polymerase. J. Biol. Chem. 262, 15330-15333.
119. Tabor, S., Huber, H. E., and Richardson, C. C. (1987) Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7. J. Biol. Chem. 262, 16212-16223.
120. Huber, H. E., Tabor, S., and Richardson, C. C. (1987) Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates. J. Biol. Chem. 262, 16224-16232.
121. Bernstein, J., and Richardson, C. C. (1988) A 7-kDa region of the bacteriophage T7 gene 4 protein is required for primase but not for helicase activity. Proc. Natl. Acad. Sci., USA 85, 396-400.
122. White, J. H., and Richardson, C. C. (1988) Gene 19 of bacteriophage T7: overexpression, purification, and characterization of its product. J. Biol. Chem. 263, 2469-2476.
123. Beauchamp, B. B., and Richardson, C. C. (1988) A unique deoxyguanosine triphosphatase is responsible for the optA1 phenotype of Escherichia coli. Proc. Natl. Acad. Sci., USA 85, 2563-2567.
124. Nakai, H., and Richardson, C. C. (1988) Leading and lagging strand synthesis at the replication fork of bacteriophage T7. Distinct properties of T7 gene 4 protein as a helicase and primase. J. Biol. Chem. 263, 9818-9830.
125. Nakai, H., and Richardson, C. C. (1988) The effect of the T7 and Escherichia coli DNA-binding proteins at the replication fork of bacteriophage T7. J. Biol. Chem. 263, 9831-9839.
126. Huber, H. E., Bernstein, J., Nakai, H., Tabor, S., and Richardson, C. C. (1988) Interactions of the DNA Replication Proteins of Bacteriophage T7. in Cancer Cells 6, Eukaryotic DNA Replication, (Eds. T. Kelly and B. Stillman), Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., pp 11-17.
127. Huber, H. E., Beauchamp, B. B., and Richardson, C. C. (1988) Escherichia coli dGTP triphosphohydrolase is inhibited by gene 1.2 protein of bacteriophage T7. J. Biol. Chem. 263, 13549-13556.
128. Bernstein, J., and Richardson, C. C. (1988) Purification of the 56-kDa component of the bacteriophage T7 primase/helicase and characterization of its nucleoside 5'-triphosphate activity. J. Biol. Chem. 263, 14891-14899.
129. Nakai, H., Beauchamp, B. B., Bernstein, J., Huber, H. E., Tabor, S., and Richardson, C. C. (1988) Formation and propagation of the bacteriophage T7 replication fork. in DNA Replication and Mutagenesis, (Eds. R. E. Moses and W. C. Summers) American Society for Microbiology, Washington D.C., pp. 85-97.
130. Rabkin, S. D., and Richardson, C. C. (1988) Initiation of DNA replication at cloned origins of bacteriophage T7. J. Mol. Biol. 204, 903-916.
131. Huber, H. E., McCoy, J. M., Seehra, J. S., and Richardson, C. C. (1989) HIV-1 reverse transcriptase: template binding, processivity, strand-displacement synthesis, and template switching. J. Biol. Chem. 264, 4.669-4,678.
132. Tabor, S., and Richardson, C. C. (1989) Selective inactivation of the exonuclease activity of bacteriophage T7 DNA polymerase by in vitro mutagenesis. J. Biol. Chem. 264, 6,447-6,458.
133. Tabor, S., and Richardson, C. C. (1989) Effect of Manganese ions on the incorporation of dideoxynucleotides by bacteriophage T7 DNA polymerase and Escherichia coli DNA polymerase I. Proc. Natl. Acad. Sci., USA 86, 4076-4080.
134. Bernstein, J., and Richardson, C. C. (1989) Characterization of the helicase and primase activities of the 63-kDa component of the bacteriophage T7 gene 4 protein. J. Biol. Chem. 264, 13,066-13,073.
135. Rabkin, S. D., and Richardson, C. C. (1990) In vivo analysis of the initiation of bacteroiophage T7 DNA replication. Virology 174, 585-592.
136. Nakai, H., and Richardson, C. C. (1990) The gene 1.2 protein of bacteriophage T7 interacts with the Escherichia coli dGTP triphosphohydrolase to form a GTP-binding protein. J. Biol. Chem. 265, 4411-4419.
137. Wurgler, S. M., and Richardson, C. C. (1990) The gene for dGTP triphosphohydrolase from Escherichia coli: structure and regulation Proc. Natl. Acad. Sci., USA 87, 2740-2744.
138. Tabor, S., and Richardson, C. C. (1990) DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Effect of pyrophosphorolysis and metal ions. J. Biol. Chem. 265, 8322-8328.
139. Huber, H. E., and Richardson, C. C. (1990) Processing of the primer for plus-strand DNA synthesis by Human Immunodeficiency Virus 1 reverse transcriptase. J. Biol. Chem. 265, 10555-10573.
1991-1995
140. Mendelman, L. V., and Richardson, C. C. (1991) Requirements for primer synthesis by bacteriophage T7 63-kDa gene 4 protein: roles of template sequence and T7 56-kDa gene 4 protein. J. Biol. Chem. 266, 23240-23250.
141. Kim, Y. T., Tabor, S., Bortner, C., Griffith, J. D., and Richardson, C. C. (1992) Purification and characterization of the bacteriophage T7 gene 2.5 protein: a single-stranded DNA binding protein. J. Biol. Chem.267, 15022-15031.
142. Kim, Y. T., Tabor, S., Churchich, J. E., and Richardson, C. C. (1992) Interactions of the gene 2.5 protein and DNA polymerase of bacteriophage T7. J. Biol. Chem. 267, 15032-15040.
143. Himawan, J., and Richardson, C. C. (1992) Genetic analysis of the interaction between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin. Proc. Natl. Acad. Sci. U.S.A. 89, 9774-9778.
144. Mendelman, L. V., Notarnicola, S M., and Richardson, C. C. (1992) Roles of bacteriophage T7 gene 4 proteins in providing primase and helicase functions in vivo. Proc. Natl. Acad. Sci. U.S.A. 89, 10638-10642.
145. Liu, Q., and Richardson, C. C. (1993) Gene 5.5 protein of bacteriophage T7 interacts with the H-NS protein of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 90, 1761-1765.
146. Wurgler, S. M., and Richardson, C C. (1993) DNA binding properties of the deoxyguanosine triphosphohydrolase of Escherichia coli. J. Biol. Chem. 268, 20046-20054.
147. Kim, Y. T., and Richardson, C. C. (1993) Bacteriophage T7 gene 2.5 protein: an essential protein for DNA replication. Proc. Natl. Acad. Sci., U.S.A. 90, 10173-10177.
148. Notarnicola, S. M., and Richardson, C. C. (1993) The nucleotide binding site of the helicase/primase of bacteriophage T7: Interaction of mutant and wild-type proteins. J. Biol. Chem. 268, 27198-27207.
149. Mendelman, L. V., Notarnicola, S. M., and Richardson, C. C. (1993) Evidence for distinct primase and helicase domains in the 63-kDa-gene 4 protein of bacteriophage T7: Characterization of a nucleotide binding site mutant. J. Biol. Chem. 268, 27208-27213.
150. Kim, Y. T., and Richardson, C. C. (1994) Acidic carboxy terminal domain of gene 2.5 protein of bacteriophage T7 is essential for protein-protein interactions. J. Biol. Chem. 269, 5270-5278.
151. Debyser, Z., Tabor, S., and Richardson, C. C. (1994) Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7. Cell 77, 157-166.
152. Mendelman, L. M., Beauchamp, B. B., and Richardson, C. C. (1994) Requirement for a zinc motif for template recognition by the bacteriophage T7 primase. EMBO J. 13, 3909-3916.
153. Hine, A., and Richardson, C. C. (1994) A functional, chimeric DNA primase: the Cys4 zinc-binding domain of bacteriophage T3 primase fused to the helicase of bacteriophage T7. Proc. Natl. Acad. Sci., U.S.A. 91, 12327-12331.
154. Tabor, S., and Richardson, C. C. (1995). A single residue in DNA polymerases of the Escherichia coli polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides. Proc. Natl. Acad. Sci., U.S.A. 91, 6339-6343.
155. Mendelman, L. V., Kuimelis, R. G., McLaughlin, L. W., and Richardson, C. C. (1995) Requirements for initiation of primer synthesis by the bacteriophage T7 primase; nucleoside analog substitutions for cytosine in a 3'-CTG-5' template recognition site. Biochemistry 34, 10187-10193.
156. Notarnicola, S. M., Park, K., Griffith, J. D., and Richardson, C. C. (1995) A domain of the gene 4 helicase/primase of bacteriophage T7 required for the formation of an active hexamer. J. Biol. Chem. 270, 20215-20224.
1996-2000
157. Kong, D., and Richardson, C. C. (1996) Single-stranded DNA binding protein and DNA helicase of bacteriophage T7 mediate homologous DNA strand exchange. EMBO J. 15, 2010-2019.
158. Kusakabe, T., and Richardson, C. C. (1996) The role of the zinc motif in sequence recognition by DNA primases. J. Biol. Chem. 271, 19563-19570.
159. Himawan, J. S., and Richardson, C. C. (1996) Biochemical analysis of the interactions between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin. J. Biol. Chem. 271, 19999-20008.
160. Yang, X-M., and Richardson, C. C. (1996) Structural and functional organization of the DNA polymerase of bacteriophage T7. J. Biol. Chem. 271, 24207-24212.
161. Bedford, E., Tabor, S., and Richardson (1997) A domain of T7 DNA polymerase that confers processivity on E. coli DNA polymerase I. Proc. Natl. Acad. Sci., U.S.A. 94, 479-484.
162. Kusakabe, T., and Richardson, C. C. (1997) Template recognition and ribonucleotide specificity of the DNA primase of bacteriophage T7. J. Biol. Chem. 272, 5943-5951.
163. Yang, X-M., and Richardson, C. C. (1997) Amino acid changes in a unique sequence of bacteriophage T7 DNA polymerase alters the processivity of nucleotide polymerization. J. Biol. Chem. 272, 6599-6606.
164. Kong, D., Nossal, N. G., and Richardson, C. C. (1997) Role of the bacteriophage T7 and T4 single-stranded DNA binding proteins in the formation of joint molecules and DNA helicase-catalyzed polar branch migration. J. Biol. Chem. 272, 8380-8387.
165. Kong, D., Griffith, J. D., and Richardson, C. C. (1997) Gene 4 helicase of bacteriophage T7 mediates strand transfer through pyrimidine dimers, mismatches, and non-homologous regions. Proc. Natl. Acad. Sci., U.S.A. 94, 2987-2992.
166. Kusakabe, T., and Richardson, C. C. (1997) Gene 4 DNA primase of bacteriophage T7 mediates the annealing and extension of ribooligonucleotides at primase recognition sites. J. Biol. Chem. 272, 12446-12453.
167. Notarnicola, S. M., Mulcahy, H. L., Lee, J., and Richardson, C. C. (1997) The acidic carboxyl-terminus of the bacteriophage T7 gene 4 helicase/primase interacts with T7 DNA polymerase. J. Biol. Chem. 272, 18425-18433.
168. Canard, B., Sarfati, R., and Richardson, C. C. (1997) Binding of RNA template to a complex of HIV-1 reverse transcriptase/primer/template. Proc. Natl. Acad. Sci., U.S.A. 94, 11280-11284.
169. Doublié, S., Tabor, S., Long, A., Richardson, C. C., and Ellenberger, T. (1998) Crystal structure of bacteriophage T7 DNA polymerase complexed to a primer-template, a nucleoside triphosphate, and its processivity factor thioredoxin. Nature 391, 251-258.
170. Park, K., Debyser, Z., Tabor, S., Richardson, C. C., and Griffith, J. D. (1998) Formation of a DNA loop at the replication fork generated by bacteriophage T7 replication proteins. J. Biol. Chem. 273,5260-5270.
171. Kusakabe, T., Baradaran, K., Lee, J., and Richardson, C. C. (1998) Roles of helicase and primase domain of the gene 4 protein of bacteriophage T7 in accessing primase recognition site. EMBO J. 17, 1542-1552.
172. Kong, D., and Richardson, C. C. (1998) Role of the acidic carboxyl-terminal domain of the single-stranded DNA binding protein of bacteriophage T7 in specific protein-protein interactions. J. Biol. Chem. 273, 6556-6564.
173. Canard, B., Sarfati, S. R., and Richardson, C. C. (1998) Enhanced binding of the reverse transcriptase of azidothymidine-resistant human-immunodeficiency-virus 1 to a 3’-AZTMP-terminated primer. J. Biol. Chem. 273, 14596-14604.
174. Lee, J., Chastain, P. D., Kusakabe, T., Griffith, J. D., and Richardson, C. C. (1998) Coordinated leading and lagging strand DNA synthesis on a mini-replication template. Mol. Cell 1, 1001-1010.
175. Frick, D. N., Baradaran, K., and Richardson, C. C. (1998) An N-terminal fragment of the gene 4 helicase/primase of bacteriophage T7 retains primase activity in the absence of helicase activity. Proc. Natl. Acad. Sci., U.S.A. 95, 7957-7962.
176. Kusakabe, T., Hine, A. V., Hyberts, S. G., and Richardson, C. C. (1999) The Cys4 zinc finger in sequence-specific, single-stranded DNA recognition: a study of bacteriophage T7 primase. Proc. Natl. Acad. Sci., U.S.A. 96, 4295-4300.
177. Guo, S., Tabor, S., and Richardson, C. C. (1999) The linker region between the helicase and primase domains of the bacteriophage T7 gene 4 protein is critical for hexamer formation. J. Biol. Chem. 274, 30303-30309.
178. Sawaya, M. R., Guo, S., Tabor, S., Richardson, C. C., and Ellenberger, T. (1999) Crystal structure of the helicase domain of the helicase-primase of bacteriophage T7. Cell 99, 167-177.
179. Canard, B., Chowdhury, K., Sarfati, R., Doublié, S., and Richardson, C. C. (1999) The motif D loop of Human Immunodeficiency Virus Type I reverse transcriptase is critical for nucleoside 5’-triphosphate selectivity. J. Biol. Chem. 274, 35768-35776.
180. Frick, D. N., and Richardson, C. C. (1999) Interaction of bacteriophage T7 gene 4 primase with its template recognition site. J. Biol. Chem. 274, 35889-35898.
181. Frick, D. N., Kumar, S., and Richardson, C. C. (1999) Interaction of ribonucleoside triphosphates with the gene 4 primase of bacteriophage T7. J. Biol. Chem. 274, 35899-35907.
182. Tseng, T. Y., Frick, D. N., and Richardson, C. C. (1999) Characterization of a novel DNA primase from the Salmonella typhimurium bacteriophage SP6. Biochemistry 39, 1643-1654.
183. Chowdhury, K., Tabor, S., and Richardson, C. C. (2000) A unique loop of bacteriophage T7 DNA polymerase interacts with DNA primase/primer complex. Proc. Natl. Acad. Sci. U.S.A. 97, 12469-12474.
2001-2005
184. Kato, M., Frick, D. N., Lee, J., Tabor, S., Richardson, C. C., and Ellenberger, T. (2001) A complex of the bacteriophage T7 primase-helicase and DNA polymerase directs primer synthesis. J. Biol. Chem. 276, 21809-21820.
185. Frick, D. N. and Richardson, C. C. (2001) DNA primases. Ann. Rev. Biochem. 70, 39-80.
186. Kumar, J. K., Tabor, S., and Richardson, C. C. (2001) Role of the carboxyl-terminal residue of the DNA polymerase of bacteriophage T7. J. Biol. Chem. 276, 34905-34912.
187. Hollis, T., Stattel, J. M., Walther, D. S., Richardson, C. C., and Ellenberger, T. (2001) Structure of the gene 2.5 protein, a single-stranded DNA binding protein encoded by bacteriophage T7. Proc. Natl. Acad. Sci., U.S.A. 98, 9557-9562.
188. Kumar, J. K., Kremsdorf, R., Tabor, S., and Richardson, C. C. (2001) A mutation in the gene encoding bacteriophage T7 DNA polymerase that renders the phage temperature sensitive. J. Biol. Chem. 276, 46151-46159.
189. Lee, S., and Richardson, C. C. (2001) Essential lysine residues in the RNA polymerase domain of the gene 4 primase-helicase of bacteriophage T7. J. Biol. Chem. 276, 49419-49426.
190. Lee, J., Chastain, P. D., Griffith, J. D., and Richardson, C. C. (2002) Lagging strand synthesis in coordinated DNA synthesis by bacteriophage T7 replication proteins. J. Mol. Biol. 301, 19-34. PDF
191. Lee, S., and Richardson, C. C. (2002) Interaction of primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7. Proc. Natl. Acad. Sci., U.S.A. 99, 12703-12708. PDF
192. Rezende, L. F., Hollis, T., Ellenberger, T., and Richardson, C. C. (2002) Essential amino acid residues in the single-stranded DNA binding protein of bacteriophage T7: Identification of the dimer interface. J. Biol. Chem. 277, 50643-50653. PDF
193. Hyland, E. M., Rezende, L. F., and Richardson, C. C. (2003) The DNA binding domain of the gene 2.5 single-stranded DNA binding protein of bacteriophage T7. J. Biol. Chem. 278, 7247-7256. PDF
194. Kato, M., Ito, T., Wagner, G., Richardson, C. C., and Ellenberger, T. (2003) Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. Mol. Cell 11, 1349-1360. PDF
195. Johnson, D., and Richardson, C. C. (2003) A covalent linkage between the gene 5 DNA polymerase of bacteriophage T7 and Escherichia coli thioredoxin, the processivity factor: fate of thioredoxin during DNA synthesis. J. Biol. Chem. 278, 23762-23772. PDF
196. Rezende, L. F., Willcox, S., Griffith, J. D., and Richardson, C. C. (2003) A single-stranded DNA-binding protein of bacteriophage T7 defective in DNA annealing. J. Biol. Chem. 278, 29098-29105. PDF
197. He, Z. G., Rezende, L. F., Willcox, S., Griffith, J. D., and Richardson, C. C. (2003) The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase. J. Biol. Chem. 278, 29538-29545. PDF
198. van Oijen, A. M., Blainey, P. C., Crampton, D. J., Richardson, C. C., Ellenberger, T., and Xie, X. S. (2003) Sequence-dependence activity of l exonuclease revealed by a multiplexed single-molecule flow-stretching assay. Science 301, 1235-1238. PDF
199. Crampton, D. J., and Richardson, C. C. (2004) Bacteriophage T7 gene 4 protein: a hexameric helicase. In The Enzymes, Vol. XXIII (Eds. D. D. Hackney and F. Tamanoi)) Elsevier Academic Press, San Diego, pp. 277-302.
200. Scholl, D., Kieleczawa, J., Kemp, P., Rush, J., Richardson, C. C., Merrill, C., Adhya, S., and Molineux. I. J. (2004) Genomic analysis of bacteriophages SP6 and K1-5, an estranged subgroup of the T7 supergroup. J. Mol. Biol. 335, 1151-1171. PDF
201. Kumar, J. K., Tabor, S., and Richardson, C. C. (2004) Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 101, 3759-3764. PDF
202. Crampton, D. J., Guo, S., Johnson, D. E., and Richardson, C. C. (2004) The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling. Proc. Natl. Acad. Sci. U.S.A. 101, 4373-8 PDF
203. He, Z., and Richardson, C. C. (2004) Effect of single-stranded DNA-binding proteins on the helicase and primase activities of the bacteriophage T7 gene 4 protein. J. Biol. Chem. 279, 22190-22197. PDF
204. Lee, S., and Richardson, C. C. (2004) The linker region between the helicase and primase domains of the gene 4 protein of bacteriophage T7: role in helicase conformation and activity. J. Biol. Chem. 279, 23384-23393. PDF
205. Kumar, J. K., Chiu, E. T., Tabor, S., and Richardson, C. C. (2004) A unique region in bacteriophage T7 DNA polymerase important for exonucleolytic hydrolysis of DNA. J. Biol. Chem. 279, 42018-42025. PDF
206. Andraos, N., Tabor, S., and Richardson, C. C. (2004) The highly processive DNA polymerase of bacteriophage T7: role of the unique amino and carboxy termini. J. Biol. Chem. 279, 50609 - 50618. PDF
207. Dutta, S., Li, Y., Johnson, D., Dzantiev, L., Richardson, C. C., Romano, L. J., and Ellenberger, T. (2004) Crystal structures of N-2-acetyaminofluorene and N-2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 101, 16186-16191. PDF
208. Hamdan, S., Marintcheva, B., Cook, T., Lee, S., Tabor, S., and Richardson, C. C. (2005) A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor. Proc. Natl. Acad. Sci. U.S.A. 102, 5096-5101. PDF
209. Lee, S., and Richardson, C. C. (2005) Acidic residues in the nucleotide-binding site of the bacteriophage T7 DNA primase. J. Biol. Chem. 280, 26984 - 26991. PDF
2006-present
210. Lee, J-B., Hite, R. K., Hamdan, S. M., Xie, S., Richardson, C. C., and van Oijen, A. M. (2006) DNA primase acts as a molecular brake in DNA replication. Nature 439, 621-624. PDF
211. Crampton, D. J., Mukherjee, S., and Richardson, C. C. (2006) DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 helicase. Mol. Cell 21, 165-174. PDF
212. Qimron, U., Lee, S., Hamdan, S. M., and Richardson, C. C. (2006) Primer initiation and extension by T7 DNA primase. EMBO J. 25, 2199-2208. PDF
213. Crampton, D. J., Ohi, M. O., Qimron, E., Walz, T., and Richardson, C. C, (2006) Oligomeric states of the bacteriophage T7 primase/helicase. J. Mol. Biol. 360, 667-677. PDF
214. Marintcheva, B., Hamdan, S. M., Lee, S., and Richardson, C. C. (2006) Essential residues in the C-terminus of bacteriohage T7 gene 2.5 single-stranded DNA binding protein. J. Biol. Chem. 281, 25831-25840. PDF
215. Lee, S., Marintcheva, B., Hamdan, S. M., and Richardson, C. C. (2006) The C-terminal residues of bacteriophage T7 gene 4 helicas-primase coordinate helicase and DNA polymerase activities. J. Biol. Chem. 281, 23841-25849. PDF
216. Shokri, L., Marintcheva, B., Richardson, C. C., Rouzina, I., and Williams. M. C. (2006) Single Molecule Force Spectroscopy of Salt-dependent Bacteriophage T7 Gene 2.5 Protein Binding to Single-stranded DNA. J. Biol. Chem. 281, 38689-38696. PDF
217. Qimron, U., Tabor, S., Marintcheva, B., and Richardson, C. C. (2006) Genome-wide screens for Escherichia coli genes affecting Infection by T7 bacteriophage. Proc. Natl. Acad. Sci. U.S.A. 103, 19039-19044. PDF
218. Johnson, D., Takahashi, M., Hamdan, S. M., Lee, S. J., and Richardson, C. C. (2007) Exchange of DNA polymerases at the replication fork of bacteriophage T7. Proc. Natl. Acad. Sci. U.S.A. 104, 5312-5317. PDF
219. Hamdan, S. M., Johnson, D. E., Tanner, N. A., Lee, J. B., Qimron, U., Tabor, S., van Oijen, A. M., and Richardson, C. C. (2007) Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. Mol. Cell 27, 539-549. PDF
220. Qimron, U., Kulczyk, A. W., Hamdan, S. M., Tabor, S., and Richardson, C. C. (2007) Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage on hosts overexpressing udk. Molecular Microbiology 67, 448-457. PDF
221. Marintcheva, B., Marintchev, A., Wagner, G., and Richardson, C. C. (2008) The acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 functions as an electrostatic shield. Proc. Natl. Acad. Sci. U.S.A. 105, 1855-1860. PDF
222. Scholle, M. D., Banach, B. S,, Hamdan, S. M., Richardson, C. C., Kay, B. K. (2008) Peptide Ligands Specific to the Oxidized Form of Escherichia coli Thioredoxin. BBA Proteins and Proteomics 1754, 1735-1741. PDF
223. Lee, S. J., Qimron, U., and Richardson, C. C. (2008) Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7. Proc. Natl. Acad. Sci. U.S.A. 105, 8908-8913. PDF
224. Tran, N., Rezende, L. F., Richardson, C. C., Tabor, S., (2008) The role of bacteriophage T7 gene 1.7 in dideoxyribonucleotide sensitivity. Proc. Natl. Acad. Sci. U.S.A. 105, 9373-9378. PDF
225. Ghosh, S., Hamdan, S. M., Cook, T. E., and Richardson. C. C. (2008) Interactions of Escherichia coli thioredoxin, the processivity factor, with polymerase and helicase. J. Biol. Chem. 283, 32077-32084. PDF
226. Hamdan, S. M., Loparo, J. J., Takahashi, M., Richardson, C. C., and van Oijen,, A. M. (2009) Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis. Nature 457, 336-339. PDF
227. Akabayov, B., Lee, S. J., Akabayov, S., Rekhi, S., Zhu, B., and Richardson, C. C. (2009) DNA Recognition by the DNA Primase of Bacteriophage T7: A Structure-Function Study of the Zinc Binding Domain." Biochemistry 48, 1763–1773. PDF
228. Satapathy, A. K., Crampton, D. J., Beauchamp, B. B., and Richardson, C. C. (2009) Promiscuous usage of nucleotides by the DNA helicase of bacteriophage T7: determinants of nucleotide specificity. J. Biol. Chem. 284, 14286-14295. PDF
229. Marintcheva, B., Qimron, U., Yu, Y, and Richardson, C. C. (2009) Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C-terminal phenylalanine. Molecular Microbiology 72, 869-880. PDF
230. Lee, S. J., Chowdhury, K., Tabor, S., and Richardson, C. C. (2009) Rescue of bacteriophage T7 DNA polymerase of low processivity by suppressor mutations affecting gene 3 endonuclease. J Virol. 83, 8418-8427. PDF
231. Hamdan, S.M., and Richardson, C. C. (2009) Motors, switches, and contacts in the replisome. Ann. Rev. Biochem. 78, 205-243. PDF 3.5MB
232. Zhu, B., Lee, S. J., and Richardson, C. C. (2009) A Trans Interaction at the Interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. J. Biol. Chem. 284, 23842-23851. PDF 1.9MB
233. Ghosh, S., Marintcheva, B., Takahashi, M. and Richardson, C. C. (2009) C-terminal phenylalanine of bacteriophage T7 single-stranded DNA-binding protein is essential for strand displacement synthesis by T7 DNA polymerase at a nick in DNA. J, Biol.Chem. 284, 30339-30349. PDF 2.0MB
234. Etson, C. M., Hamdan, S. M., Richardson, C. C. and van Oijen, A. M. (2010) Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA. Proc. Natl. Acad. Sci. U.S.A. 107, 1900-1905. PDF
235. Kulczyk, A. A., Tanner, N. A., Loparo, J. J., Richardson, C. C., and van Oijen, A. M. (2010) Direct observation of enzymes replicating DNA using a single-molecule DNA stretching assay. J. Vis. Exp. 10, 3791/1689. Link
236. Satapathy, A. K., Kochaniak, A., Mukherjee, S., Crampton, D. J., van Oijen,, A., and Richardson,, C. C. (2010) Polymerase-assisted DNA unwinding by bacteriophage T7 helicase: role of the central β-Hairpin of the helicase. Proc. Natl. Acad. Sci. U.S.A. 107, 6782-6787. PDF
237. Lee, S. J., Zhu, B., Hamdan, S. M., and Richardson, C. C. (2010) Mechanism of sequence-specific template recognition by the DNA primase of bacteriophage T7. Nucleic Acid Res. 38, 4372-4383. PDF
238. Ghosh, S., Hamdan, S. M., and Richardson, C. C. (2010) Two modes of interaction of the single-stranded DNA binding protein of bacteriophage T7 with the DNA polymerase-thioredoxin complex. J. Biol. Chem. 285, 18103-18112. PDF
239. Zhu, B., Lee, S. J., and Richardson, C. C. (2010) Direct role for the RNA polymerase domain of T7 primase in primer delivery. Proc. Natl. Acad. Sci. U.S.A. 107, 9099-9104. PDF
240. Tran, N. Q., Lee, S. J., Richardson, C. C., and Tabor, S. A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7. (2010) Mol. Microbiol. 77, 492-504. PDF
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